The Variant Allele Frequency of the lncRNA Prostate Cancer-Associated Noncoding RNA 1 (PRNCR1) rs1456315 C/T Polymorphism in Saudi Population and Colorectal Cancer Risk

ingle-nucleotide polymorphisms (SNPs) in long noncoding RNA (lncRNA) genes are associated with the onset and progression of multiple cancers humans. These SNPs potential biomarkers for predicting cancer risk. The variable frequency lncRNA prostate cancer-associated 1 (PRNCR1) rs1456315 C/T polymorphism may affect different ethnic groups differently, however, information lacks Saudi population. aim this study was to assess allelic distribution PRNCR1 Arabian population, as well compare it other populations around world. PUBMED (Medline) related web-databases were referred extract data from epidemiological studies performed groups. variant allele (C) found be 34.62% a significantly observed USA (p=0.01), Iran (p < /em><0.007) China (p=0.01) ethnicity, when occurrence is compared those populations. Present results reveal distinct pattern which due differences. findings could assist risk assessment people harbouring SNP their subsequent susceptibility.